HYPOPITUITARISM IN LANGERHANS CELL HISTIOCYTOSIS SEVEN CASES AND LITERATURE REVIEW

Thyrotropin deficiency was diagnosed in that same year. Show more Show less. Few studies have measured prolactin secretion in patients with histiocytosis. The two patients with ECD were treated with systemic corticosteroids and immunomodulators as described below. SNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.

DI is usually permanent. Localized forms of LCH usually have a slow course and a good response to treatment, 4 while systemic forms involving liver, spleen, bone or lung, young adults, or poor response to chemotherapy are poor prognostic factors. Median age at diagnosis was 38 years range, 3— These cells can best be identified by their immunoreactivity for the antibodies to the CD1a antigen anti-CD1a and to langerin anti-CD Hormone measurements were performed at the start of clinical signs and every 1—2 years for axis re-evaluation..

Gonadotropin deficiency is the second most common deficiency reported in the literature.

Hypopituitarism in langerhans cell histiocytosis: seven cases and literature review.

Langerhans cell histiocytosis—clinical and epidemiological aspects. The three patients with normal pituitary MRI at diagnosis showed no radiographic changes during follow-up. A computed tomography CT scan confirmed the presence of a bone-destroying tumour affecting these ribs. LCH is characterised histologically by an uncontrolled monoclonal proliferation of abnormal Langerhans cells: To improve our services and products, we use “cookies” own or third parties authorized to show advertising related to client preferences through the analyses of navigation customer behavior.

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Langerhans cell Histiocytosis in adults. Systemic therapy is indicated to prevent irreversible damage to normal tissue and long-term consequences. Langerhans cell histiocytosis of the female genital tract. Subtotal resection was performed, and the histological examination was consistent with ECD.

Treatment of patients with hypothalamic—pituitary lesions as adult-onset Langerhans cell histiocytosis. Continuing navigation will be considered as acceptance of this use.

A review of the clinical and radiological findings. The skeletal survey showed lytic lesions histiocytosia the left parasagittal area of the skull and the right femoral neck refer to Fig.

hypopituitarism in langerhans cell histiocytosis seven cases and literature review

histiocytsois English pdf Article in xml format Article references How to cite this article Automatic translation. Hypopituitarism in Langerhans cell histiocytosis: Show more Show less. Report from the International Registry of the Histiocyte Society. Int J Hematol, 94pp. Sella-suprasellar mass in a patient with Erdheim—Chester disease.

At this follow-up visit the patient was clinically well, but the skeletal isotope scan revealed areas of abnormally increased uptake in the anterior aspects of the 7th and 8th ribs on the right side. Today most investigators consider LCH to result from an aberrant immune response, but the stimulus for clonal Langerhans sevfn proliferation remains unknown.

Control pituitary MRIs showed no changes. Histological examination of a biopsy from the lesion was consistent with ECD. Please anx this article as: DI is usually permanent.

Hypopituitarism in langerhans cell histiocytosis: seven cases and literature review.

The most common radiographic finding is the loss of the hyperintense signal of the neurohypophysis, present in almost all patients with DI. Diagnosis is not made in a substantial proportion of cases due to the variety of nonspecific symptoms. It is characterised by extreme clinical heterogeneity that can bring it to the attention of a variety of healthcare workers. Hormonal and biochemical tests showed DI and secondary hypogonadism, for which replacement therapy was started.

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Treatment of Langerhans cell histiocytosis. Langerhans cell histiocytosis infiltration into pancreas and kidney. Pituitary deficiencies in our study were not exactly comparable to those reported in the literature, which liiterature patients diagnosed with histiocytosis both with and without HPA involvement.

Table 3 shows the systemic involvement and secen administered in our series. Hormone measurements were performed at the start of clinical signs and every 1—2 years for axis re-evaluation. Inthe common pathology of these three conditions was recognised and the term histiocytosis X was introduced to name them collectively.

hypopituitarism in langerhans cell histiocytosis seven cases and literature review

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